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Expires On
June 18, 2019
June 18, 2019
Nocturnal call mac os. Completion Time
60 minutes
60 minutes
Topic(s)
Anticoagulation Mgmt
Anticoagulation Mgmt
Scroll to the Bottom of this Information to Begin this Course
This activity is jointly provided by theAlbert Einstein College of Medicine and Montefiore Medical Center in Joint Providership with PlatformQ Health Education, LLC.
Supported by an independent educational grant from Portola Pharmaceuticals, Inc.
Credit Available
- Physicians — maximum of 1.0 AMA PRA Category 1 Credit(s)™
Nightly college mac os. All other health care professionals completing this course will be issued a statement of participation.
Target Audience
This activity is intended for US‐based hospitalists (including those in emergency medicine, intensive care, and surgery), internal medicine and primary care providers, cardiologists, nurse practitioners, physician assistants, nurses, pharmacists, and other health care providers who care for patients at risk of thromboembolic events.
Learning Objectives
Upon completion of this activity, participants should be able to:
- Stratify risk for major bleeding in patients requiring anticoagulation
- Summarize clinical efficacy and safety data of current and emerging reversal agents for NOAC‐associated bleeds
- Apply clinical standard of care in the management of bleeding from access to selective anticoagulation reversal agents to effective overall supportive bleeding management strategies
- Employ best practices for anticoagulation therapy reintroduction
Faculty
Christian T. Ruff, MD, MPH
Director of General Cardiology
Brigham and Women’s Hospital
Assistant Professor of Medicine
Harvard Medical School
Investigator
TIMI Study group
Brigham and Women’s Hospital
Assistant Professor of Medicine
Harvard Medical School
Investigator
TIMI Study group
Elaine Hylek, MD, MPH
Professor of Medicine
Boston University School of Medicine
Boston University School of Medicine
Physician Accreditation Statement
The activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Albert Einstein College of Medicine and PlatformQ Health Education, LLC. Albert Einstein College of Medicine is accredited by the ACCME to provide continuing medical education for physicians.
Physician Credit Designation
Live Internet Activity
Albert Einstein College of Medicine designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Albert Einstein College of Medicine designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Enduring Material
Albert Einstein College of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Albert Einstein College of Medicine designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
Disclosures of Conflicts of Interest
Presenter
Christian T. Ruff, MD, MPH
![Mac Mac](https://appletoolbox.com/wp-content/uploads/2020/07/Control-Center-macOS-Big-Sur.jpg)
- Consulting Fee: Bayer, Bristol Myers Squibb, Boehringer Ingelheim, Daiichi Sankyo, Janssen, MedImmune, Pfizer, Portola
- Contracted Research: Boehringer Ingelheim, Daiichi Sankyo, MedImmune
Elaine Hylek, MD, MPH
- Consulting Fee: Boehringer Ingelheim, Bristol Myers Squibb/Pfizer, Janssen, Medtronic Portola
- Scientific Symposia Lecture: Boehringer Ingelheim, Bristol Myers Squibb/Pfizer
Peer Reviewers
- Henny Billett, MD: Consulting Fees: Kedrion, BPL Advisory, Bayer
Contracted Research: Janssen - Victor B. Hatcher, PhD: No disclosures to report relevant to this activity
Providers
Einstein-Montefiore Center for Continuing Medical Education
The Center for Continuing Medical Education (CCME) staff at Albert Einstein College of Medicine has no disclosures to report relevant to this activity.
The Center for Continuing Medical Education (CCME) staff at Albert Einstein College of Medicine has no disclosures to report relevant to this activity.
PlatformQ Health Education, LLC
Hamsa Jaganathan, Medical Director has nothing to disclose relevant to this activity.
Alissa Yost, Senior Program Manager has nothing to disclose relevant to this activity.
Hamsa Jaganathan, Medical Director has nothing to disclose relevant to this activity.
Alissa Yost, Senior Program Manager has nothing to disclose relevant to this activity.
Method of Participation
There are no fees to participate in this activity. To receive credit, participants must (1) read the target audience, learning objectives, and disclosure statements, (2) complete the educational activity online, and (3) complete the posttest and activity evaluation. It is estimated that this module will take approximately 1 hour to complete. To receive AMA PRA Category 1 Credit(s)™, participants must receive a minimum score of 70% on the posttest.
Course Viewing Requirements
Supported Browsers:
Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6.0+ for Mac OSX 10.7 and above
Internet Explorer 8.0+ for Windows 2003, Vista, XP, Windows 7, Windows 8.1 and above
Google Chrome 28.0+ for Windows, Mac OS, or Linux
Mozilla Firefox 23.0+ for Windows, Mac OS, or Linux
Safari 6.0+ for Mac OSX 10.7 and above
Supported Phones & Tablets:
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above.
Android 4.0.3 and above
iPhone/iPad with iOS 6.1 or above.
Disclaimer
The material is prepared based on a review of multiple sources of information but is not exhaustive of the subject matter. Therefore, health care professionals and other individuals should review and consider other publications and materials about the subject matter other than relying solely on the information contained in this material.
The information presented at this CME program represents the views and opinions of the individual presenters, and does not constitute the opinion or endorsement of, or promotion by Albert Einstein College of Medicine, CardioCareLive, PlatformQ Health Education, LLC or the program grantor. Reasonable efforts have been made to present educational subject matter in a balanced, unbiased fashion and in compliance with regulatory requirements. Each participant must use his/her personal and professional judgment when considering further application of this information, particularly as it may relate to patient diagnostic or treatment decisions including, without limitation, FDA-approved uses and any off-label uses.
Contact Information
Bleeding Mac Os Catalina
For any technical issues or issues with your CME Certificate, please contact CardioCareLive at 877-394-1306 or at [email protected]
Accredited Provider: Montefiore Medical Center, CCME, 3301 Bainbridge Avenue, Bronx, New York 10467, or via phone at (718) 920-6674, or via fax to (718) 798-2336, or via email to [email protected]
PlatformQ Health Privacy Policy:
By clicking “Start Activity” you are agreeing to PlatformQ Health’s privacy policy. PlatformQ Health takes your privacy very seriously. The full Privacy Policy found here describes (i) the types of information we collect from you when you visit our Site; (ii) how we use the information we collect; (iii) with whom and why we share it; and (iv) the choices we offer regarding our use of the information. We also describe how to contact us about our privacy practices.
Information we collect is primarily used to communicate with program participants, award CME/CE credits, manage user accounts, recommend relevant programs and perform data analysis to inform educational outcomes.
In plain English, here is what we affirm:
- You can change your registration profile at any time from our “Profile” page
- To request any of these changes without logging in, please call us at 1 (877) 394-1306 or email us at [email protected]
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- EU citizens can request a complete record of their account and/or request to have their personal data expunged by contacting [email protected] with the subject line “Data Request”
You acknowledge and agree that by beginning this activity, you have affirmatively agreed to this Privacy Policy and consented to receiving electronic messages in conformance with this Privacy Policy. Please read the full privacy policy located at: www.platformqhealth.com/privacy-policy/
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WHAT IS MAC (MYCOBACTERIUM AVIUM COMPLEX) AND HOW IS IT DIAGNOSED AND TREATED?
- Formerly known as “atypical mycobacteria”, “atypical TB”, or “atypical AFB” and currently as “nontuberculous mycobacteria” or “NTM”. NTM includes all types or species of mycobacteria (including MAC) other than the germ of tuberculosis (TB).
- Related to Mycobacterium tuberculosis (Mtb) but it is not TB (tuberculosis).
- NTM includes a number of different species, but the most common one causing chronic lung disease is MAC.
- MAC is not spread person to person like Mtb. MAC is not contagious.
- MAC lung disease seen in HIV negative (non-AIDS) patients is a chronic lung infection and early-on is often misdiagnosed as chronic bronchitis or recurrent pneumonia.
- MAC Lung Disease is acquired from the environment (soil, air, natural waters, tap water, etc.)
- Scientists and physicians who have studied MAC believe people who develop MAC lung disease become infected because of a defect in the structure or function of their lungs (especially a disease called bronchiectasis) or in their immune systems.
- Damaged lung tissue can result from previous TB, heavy smoking, and a breathing tube disease called bronchiectasis.
- Bronchiectasis is a breathing tube (bronchial) disorder characterized by excessive mucus production, cough, and susceptibility to certain infections such as MAC or infection caused by bacteria such as Pseudomonas aeruginosa.
- Disease in men commonly relates to smoking while disease in women (non-smoking) usually relates to bronchiectasis.
- The average age of patients with MAC lung disease in men is 55 years and 67 years in women.
- Men are more likely to have cavitary MAC (holes in their lungs). Women are more likely to have non-cavitary, nodular MAC.
- Diagnosis of MAC lung disease usually requires:
- Medical history with records of symptoms:
- Cough, sputum production, shortness of breath
- Loss of appetite (anorexia is the medical term) weight loss
- Severe fatigue or tiredness with inability to perform daily tasks
- Rarely coughing up blood (hemoptysis is the medical term)
- Fever, night sweats
- Chest x-ray (a picture of your lungs internally)
- High resolution CT scan (HRCT) (similar to an x-ray but a more detailed picture)
- Sputum culture – several sputum cultures are usually performed. Your specimen coughed from your lungs is examined under a microscope (AFB smear) and also placed on special media to grow mycobacteria (AFB culture).
- Bronchoscopy – may be necessary in some cases (especially if you can not cough up sputum) but not all, and involves putting a tube down into your lungs to obtain specimens for culture.
TREATMENT OF MAC LUNG DISEASE REQUIRES A MULTI-DRUG REGIMEN (MORE THAN ONE DRUG).
- MAC is resistant to ordinary antibiotics.
- Combination of 3 drugs (all FDA approved)/dosages are based upon your clinical history, age, weight, and symptoms.
- Clarithromycin (Biaxin) or Azithromycin (Zithromax)
- Rifampin (Rifadin) or Rifabutin (Mycobutin)
- Ethambutol (Myambutol)
- The combination of medicines is given until no more MAC germs can be grown by culture of your sputum for 1 year. Average treatment period is about 15-18 months.
- Monthly sputum cultures are performed while you are on therapy and periodically when you finish your therapy to be sure your MAC is gone.
- The 3-drug treatment may be given 3 times weekly (preferably Monday-Wednesday-Friday) or daily.
- Data from previous treatment trials tells us that most patients (approximately two-thirds) who have no previous treatment of their MAC and who can tolerate the appropriate medicines will get better and be “cured” of their MAC lung disease.
- Patients who have failed a prior drug regimen of > 6 months for their MAC are more likely to fail the standard drug regimen (almost 50%).
- Patients who take the 3-drug regimen for less than 1 year with negative cultures are more likely to relapse with disease with their same MAC strain.
- Patients who fail therapy after taking the 3 medicines are usually required to take additional medicines. Injectables which may be useful include:
- Streptomycin or Amikacin
- Amikacin can also be given by inhalation (aerosolized) and is less toxic when given in this manner.
- Monthly laboratory blood tests that include a complete blood count and comprehensive metabolic panel (CBC and CMP) to check for possible damage to blood cells, kidneys, and liver.
- Most common potential side effects/complications of medicines:
- Clarithromycin : Loss of appetite, diarrhea, nausea, abdominal pain, abnormal liver function tests (blood tests), bitter taste, mild allergic rash.
- Azithromycin : Diarrhea, nausea, abdominal pain, abnormal liver function tests (blood tests), decreased hearing, tinnitus (sounds in ears).
- Rifampin : Nausea, vomiting, liver damage, decreased platelets (cells which clot blood), body secretions (urine primarily) are orange/red.
- Rifabutin : Nausea, vomiting, decreased platelets, decreased white blood cells (cells that fight infection), eye pain (uveitis), diffuse muscle and joint aches, skin pigmentation (yellow).
- Ethambutol : Decrease in vision (especially color vision), blurriness.
- Streptomycin : Kidney damage, sounds in ears (tinnitus), hearing loss, poor balance, numbness, tingling, muscle damage, fever, headache.
- Amikacin : Kidney damage, tinnitus, hearing loss, poor balance.
If you experience these or other additional problems, you should discuss them with your physician. - Amikacin by inhalation (aerosolization) decreases toxicity to above adverse events.
Provide a list of your current medicines to your physician so he can determine any possible contra-indications.
PULMONARY FUNCTION TESTING
What is a pulmonary function test?
Pulmonary function testing is a way to measure your breathing capacity and, therefore is an objective measure of how well you are breathing. There are several types of breathing tests that can be done during pulmonary function testing including spirometry, lung volumes and diffusing capacity. A technician will explain what you need to do during each test and will coach you during the tests to help you give a good effort. All breathing tests require more than one measurement so that you will be asked to make more than one effort for each test. Spirometry is the most commonly performed breathing test. It requires you to take in as deep a breath as possible and then blow out the air in your lungs as forcefully and fully as possible. Spirometry, therefore, measures how much air you breathe in and out and how fast you breathe air in and out. Spirometry is frequently performed at baseline and then after you have inhaled a bronchial dilating drug (breathing medicine) to evaluate the effect of medication on your breathing function. Blink (itch) (protocolseven) mac os. As with all pulmonary function tests, it is very important that you make a maximal effort to insure accurate assessment of your breathing function. Lung volumes are performed while you are sitting in a small chamber called a plethysmograph (or body box) and provide further information about how much air you breathe in and out. You will be asked to perform different breathing techniques such as blowing into a tube while in the chamber. Lung volumes are usually not performed unless there are abnormalities found on spirometry. The diffusing capacity is one measure of how well your lungs move oxygen from the lungs into the blood. The results of pulmonary function testing can tell you and your doctor how much your lungs have been affected by a disease process and help determine if specific therapy can be of benefit to you. They can also be useful for evaluating the effects of a disease or treatment over time. You will be given specific instructions about what to do with your own breathing medications when the breathing tests are scheduled. Pulmonary function testing usually takes between ½ to 1 ½ hour to complete, depending on how many of the pulmonary function tests you are asked to complete.
Also see the http://www.uthct.edu website for further information including on how to arrange a clinic visit for expert consultation on MAC. Other centers that can also provide such consultation are found under the List of Treating Institutions.